Lipid droplets comprise hydrophobic core and hydrophilic monolayer

In our organism, all lipid droplets comprise a hydrophobic core (with diacylglycerols, triacylglycerols, cholesteryl esters, or retinyl esters and free fatty acids) and a hydrophilic monolayer (with phospholipids).

  • The surface of lipid droplets is covered by proteins that serve structural and metabolic functions. Proteins can bind on the surface of droplets or extend deeply into the core. The specific repertoire of proteins differs for lipid droplets in different cell types and even among different droplets within a cell. Fatty acids (one of “initial lipids” that serve as building blocks for different lipids) regulate overall lipid metabolism by binding nuclear receptors that modulate gene transcription. Droplets store energy that is used both in the organs of origin and in distant organs.
  • Author of text and image: Iryna Ilkavets

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