Detailed Simulation of Blood Flow and Drug Metabolization

  • At the organ scale, blood is distributed along blood vessels of decreasing size to the so-called sinusoids where an exchange of substances (e.g., drugs) between blood and cells takes place.

  • Scientists from Virtual Liver Network are interested in physiology-based models which mechanistically link liver perfusion and cellular processes, in particular in cases of diseases of spatially varying extent, such as lipid accumulations in steatotic livers. For this purpose, an accurate geometric representation of the liver and its blood vessels (obtained from an in vivo CT scan) is combined with so-called pharmacokinetics models. These describe in effective form how fast a given substance is transferred from the blood into the liver cells and how it is metabolized there.
  • The video above shows simulation results for the substance CFDA SE (carboxyfluorescein diacetate succinimidyl ester) injected into the blood flow through an isolated mouse liver. At first, no CFDA SE is present in the blood vessels and the liver tissue (shown in blue). Following the infusion (high concentration visualized in red), the substance enters through the supplying blood vessels and gets distributed throughout the organ and into the draining blood vessels. After the infusion stops, CFDA SE is washed out of the organ within about half a minute.
  • Authors: Lars Küpfer and Ole Schwen

  • Scientific publication: Spatio-Temporal Simulation of First Pass Drug Perfusion in the Liver
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