Scientists of the Virtual Liver Network generated a mathematical model of glucose turnover in the liver. Main steps to generate such a model are:

Discover the Liver

Scientists generated a mathematical model that describes glucose turnover in the liver

Scientists of the Virtual Liver Network generated a mathematical model of glucose turnover in the liver. Main steps to generate such a model are:

VLN glucose metabolism by Matthias Koenig is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.

Based on a work at http://www.charite.de/sysbio/people/koenig/

Detailed Simulation of Blood Flow and Drug Metabolization

Large-scale measurement of cellular properties

To ensure the validity of the models developed in the Virtual Liver project, they are validated by means of experimental data. Here, the validation of scale-independent models is a particular challenge. The data must be both fine-grained enough to describe the properties of individual cells, and comprehensive enough to represent their distribution across the organ.

3D reconstruction of serial whole slide sections

In order to understand liver functions, the physiology and morphology of microscopic tissue sections are invaluable. However, one section is extremely thin (4 µm) and thus captures only a small fraction of the whole organ. This means disregarding a lot of tissue information as well as their 3D correlation.